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The stage is set for a fascinating top-flight contest as table-toppers Arsenal entertain bottom-placed Wolves to the Emirates Stadium.

Confirmed Sides

Mikel Arteta's side have opted for three changes from the team that endured a 2-1 loss at Aston Villa last weekend. The French defender, Viktor Gyökeres and Gabriel Martinelli all start in the lineup. The captain and the Spanish midfielder drop to the bench, while Riccardo Calafiori is absent. Saliba is back after sitting out a run of games through injury.

Wolves also make three adjustments to their starting XI after being soundly beaten 4-1 at Molineux by United on Monday evening. Matt Doherty, the Brazilian midfielder and the South Korean forward are recalled. Ki-Jana Hoever and Jhon Arias are on the substitutes, while Bellegarde is omitted altogether.

Starting Elevens

Arsenal: Raya, White, Saliba, Hincapie, Timber, Eze, Zubimendi, Rice, Saka, Gyokeres, Martinelli.
Substitutes: Arrizabalaga, Odegaard, Gabriel Jesus, Norgaard, Trossard, Madueke, Nwaneri, Merino, Lewis-Skelly.

Wolverhampton Wanderers: Johnstone, Mosquera, Agbadou, Toti Gomes, Doherty, Joao Gomes, Andre Trindade, Krejci, Wolfe, Larsen, Hwang.
Bench: Tchatchoua, Mane, Lopez, Hoever, Chirewa, Arokodare, Arias, Santiago Bueno, Jose Sa.

Match Official: Robert Jones
Video Assistant Referee: John Brooks

The Setup

Good evening! And I mean, look at this …

The table reveals a striking story. The hosts sit comfortably at the top of the Premier League, while their opponents occupy the bottom of the league.

… however, even though this will be the 42nd occasion the Premier League leaders have taken on the side at the foot of the entire table – with 30 victories from 41, with seven draws – which team is responsible for two of the four historical shocks? Why, Wolverhampton Wanderers, of course! Therefore, although Mikel Arteta will undoubtedly be anticipating another victory, the Wolves boss must know that underdogs sometimes succeed, and you never know. Kick-off is at 8pm GMT. The action is imminent!

^{(The remaining last-over-first wins in the Premier League era are Oldham Athletic's 1-0 win over Manchester United in March 1993, and Tottenham Hotspur – yeah, a surprising one - defeating Liverpool in November 2008.)}